Role of Charged Lipids in Membrane Structure

Role of Charged Lipids in Membrane Structure An observation of BMC Bioinformatics Journal  on the Role of charged lipids in membrane structure In this journal, the experimenters make observations to note in saying that charged lipids play and important role in what they call a phenomenon. This includes lipid protein binding, membrane potential and membrane permeation (Pà ¶yry Vattulainen, 2016). In this journal the experimenters note the following; effects of charged lipids on membrane properties and effect of charged lipids on membrane proteins (Pà ¶yry Vattulainen, 2016). They then go on to note what they call the interplay between charged lipids and Nano sized molecules or particles (Pà ¶yry Vattulainen, 2016). The objectives of the experimenters in this journal review and discuss the recent findings that describe charged lipids as active players in the membrane system (Pà ¶yry Vattulainen, 2016). The experimenters in this journal will discuss how charged lipids affect membrane properties. Then further expand on how their charged nature comes into play in lipid-protein interactions (Pà ¶yry Vattulainen, 2016). In further detail the experimenters focused on the recent simulation work done in the field and integrate the work in recent simulations with that of their own observations to experiments (Pà ¶yry Vattulainen, 2016). The tested hypotheses in this journal is represented as testing Phosphatidylcholine (PS) for key players in preprogrammed cellular death as discussed by computer generated simulations about the properties of charged lipids (Pà ¶yry Vattulainen, 2016). Who in turn also plays many roles in a variety of different processes. The experimenters noted that the null hypothesis was testing phosphatidylinositol (PI) which is often involved in the modulation of membrane receptors and their signaling processes and testing to see if there was any significant difference between the two variables due to their role in many biological processes (Pà ¶yry Vattulainen, 2016). The materials and methods the experimenters introduce in this journal are preexisting scenarios. Having done their own research on charged lipids the experimenters inputted their data to continue the experimentation. The experimenters in this journal mention that that dependent variables are the various simulations of the (PS) (PI) that can get to the importance of atomistic details (Pà ¶yry Vattulainen, 2016). The experimenters used the force fields for complex charged lipids as the independent variables to change or manipulate the experiment. Specifically mentioning than any model can only be as good as the underlying force field referencing Insight into the Properties of Cardiolipin Containing Bilayers from Molecular Dynamics Simulations, Using a Hybrid All-Atom/United-Atom Force Field. In this journal the experimenters reference several terms. These terms represent a few of the many biologically relevant processes where charged lipids are highlighted in the importance of understanding the function of charged lipids in cells (Pà ¶yry Vattulainen, 2016): Phosphatidylcholine or (PS): is one of the key players in programmed cell death and phosphatidylinositol or (PI): which is often involved in the modulation of membrane receptors and their signaling processes. Using already existing simulations the experimenters manipulate the force fields of the lipid bilayers in order to test the hypotheses. In this journal the results show that the experimenters have failed to reject the null hypothesis in determining that the simulation data has shown in what they refer to as a convincing manner that specific details are often important in determining the properties of charged lipids. It is not only the charge that matters. If it did, then lipids such as PS and PI would largely have the same effects, which is the not the case (Pà ¶yry Vattulainen, 2016). The experimenters in this journal note that the (PI) lipids have been observed to cluster around several human RTKs and around EGFR and state the same could be said about the (PS) except that the (PI) has a better chance in interacting with proteins than the latter (Pà ¶yry Vattulainen, 2016). The experimenters also note that the (PI) chemical details matter as well because the different properties of the (PI) lipids show. In conclusion the experimenters mention that (PS) (PI) have both had their fair share of attention in biology. The experimenters continue to state that when (PS) (PI) are incorporated into bilayers they have been shown to increase the ordering of phosphatidylcholine (PC) chains and state they stiffen the bilayers. The experimenters making a considerable note; state that there has been a great deal of a lack of attention being paid to diffusion. Or as they put it dynamics of charged lipids. Being specific in noting that there is a clear void for future research to fill (Pà ¶yry Vattulainen, 2016). In this journal the experimenters mentioned that future work would be more than welcomed in this field stating that this field of study for complex charged lipids is not a simple feat when pertaining to force fields (Pà ¶yry Vattulainen, 2016). Comparatively speaking, the experimenters state that it is difficult to find commonalities especially when the models being tested in various studies are based on different force fields. Lastly and concluding the journal the experimenters state that studies based on the same force field work would most likely have more reliable trends that are revealing and would be most welcome. References Cited Pà ¶yry, S. Vattulainen, I. (2016). Role of charged lipids in membrane structures Insight given by simulations. Biochimica Et Biophysica Acta (BBA) Biomembranes, 1858(10), 2322-2333. D. Aguayo, F.D. Gonzalez-Nilo, C. Chipot, Insight into the properties of cardiolipin  containing bilayers from molecular dynamics simulations, using a hybrid all-atom/united-atom force field, J. Chem. Theory Comput. 8 (2012) 1765-1773. Abstract Reference: http://dx.doi.org/10.1016/j.bbamem.2016.03.016

Musicians have a responsibility to serve as role models to our youth :: Music

Musicians have a responsibility to serve as role models to our youth I strongly disagree with this statement because music artists have the right to express what ever subject they wish. Musicians do have to serve as role models to our youth through their actions, if that is their target market, but they do not have to take any responsibility what so ever for what teenagers choose to listen to or the actions they choose to take because of artists lyrics. The lyrics in many musicians? songs, especially ?rap? music should not be taken seriously, because a number of music artists have said that the lyrics in their songs are not meant to be taken seriously. Many rap artists use extremely exaggerated and profound lyrics (which are not to be taken seriously) to portray a message. There has been much debate over whether musicians should be banned from releasing music with explicit lyrics, especially by parents. Ozzie Osbourne has been taken to court on three occasions because of parents that accused him of influencing their sons? actions due to the explicit lyrics in his songs. Each of the boys had committed suicide, and on all three occasions parents believed that Ozzie Osbourn?s lyrics contributed to, or were the main cause of their sons? unfortunate deaths. But in all three court cases Ozzie Osbourne was not held accountable for the actions of the parents children, because music artists are allowed to express themselves freely. Even though all musicians have the right of ?freedom of speech? there is warning stickers on all CD?s such as ?Explicit content MA 15+? or ?High Course Language? etc. These labels help differentiate music with explicit lyrics/content from music that has no explicit content. The labels warn all parents that if their child or teenager is under the age of 16, that this music may not be suitable for them to listen to.

Mandela

Nelson Rolihlahla Mandela was a South African anti-apartheid revolutionary, politician, and philanthropist who served as President ot South Africa trom 1994 to 1999. He was south Africa's first black chief executive, and the first elected In a fully representative democratic election. HIS government focused on dismantling the legacy of apartheid through tackling Institutionalized racism, poverty and Inequality, and fostering racial reconciliation. Politically an African nationalist and democratic socialist, he served as President of the African National Congress from 1991 to 1997.Internationally, Mandela was Secretary General of the Non-Aligned Movement from 1998 to 1999. A Xhosa born to the Thembu royal family, Mandela attended the Fort Hare University and the University of Witwatersrand, where he studied law. Living in Johannesburg, he became involved in anti-colonial politics, joining the ANC and becoming a founding member of its Youth League. After the South African National Part y came to power in 1948, he rose to prominence in the ANC's 1952 Defiance Campaign, was appointed superintendent of the organization's Transvaal chapter nd presided over the 1955 Congress of the People.Working as a lawyer, he was repeatedly arrested tor seditious activities and, with the ANC leadership, was unsuccessfully prosecuted In the Treason Trial from 1956 to 1961 Although Initially committed to non-violent protest, he co-founded the militant umkhontowe Slzwe In 1961, In association with the South African Communist Party, leading a sabotage campaign against the apartheid government. In 1962, he was arrested, convicted of conspiracy to overthrow the state, and sentenced to life Imprisonment in the RivoniaTrial. c Mandela served over 27 years in prison, Initially on Robben Island, and later in Pollsmoor Prison and Victor Verster Prison. An international campaign lobbied for his release. He was released in 1990, during a time of escalating civil strife. Mandela joined negotiatio ns with President F. W. de Klerk to abolish apartheid and establish multiracial elections in 1994, in which he led the ANC to victory and became South Africa's first black president. He published his autobiography in 1995.During his enure in the Government of National unity he invited several other political parties to join the cabinet. As agreed to during the negotiations to end apartheid In South Africa, he promulgated a new constitution. He also created the Truth and Reconciliation Commission to investigate past human rights abuses. While continuing the former government's liberal economic policy, his administration also Introduced measures to encourage land reform, combat poverty, and expand healthcare services. Internationally, he acted as mediator between Libya and the unitedKingdom in the Pan Am Flight 103 bombing trial, and oversaw military Intervention In Lesotho. He declined to run for a second term, and was succeeded by his deputy, Thabo Mbeki. Mandela became an elder sta tesman, focusing on charitable work in combating poverty and HIWAIDS through the Nelson Mandela Foundation. mandela By ericJang politician, and philanthropist who served as President of South Africa from 1994 to 1999. He was South Africa's first black chief executive, and the first elected in a fully representative democratic election.His government focused on dismantling the egacy of apartheid through tackling institutionalized racism, poverty and inequality, Johannesburg, he became involved in anti-colonial politics, Joining the ANC and repeatedly arrested for seditious activities and, with the ANC leadership, was unsuccessfully prosecuted in the Treason Trial from 1956 to 1961. Although initially committed to non-violent protest, he co-founded the militant Umkhonto we Sizwe in 1961, in association with the South African Communist Party, leading a sabotage conspiracy to overthrow the state, and sentenced to life imprisonment in the RivoniaTrial. c Mandela served over 27 years in p rison, initially on Robben Island, and later in tenure in the Government of National Unity he invited several other political parties to Join the cabinet. As agreed to during the negotiations to end apartheid in South the former government's liberal economic policy, his administration also introduced services. Internationally, he acted as mediator between Libya and the United Kingdom in the Pan Am Flight 103 bombing trial, and oversaw military intervention in combating poverty and HIV/AIDS through the Nelson Mandela Foundation.

The American Dream - 823 Words

Many people have different ideas of what the American Dream is and what it takes to make it a reality. The most common and the most accurate idea of the American Dream is for all to have the opportunity to have a chance at living a nice life. This includes all immigrants and anyone else who seems to lack better opportunities often. The American Dream is the belief that anyone, regardless of race, class, gender, or nationality, can be successful in America (read:rich) if they just work hard enough (Wulick). The American Dream is also influenced by those that have money and are successful. These people are looked up to as a goal when it comes to a better life. The American dream also includes overall happiness that stems from a†¦show more content†¦The slightest improvement within their life is better than nothing at all. It gives hope to others that are considering pursuing the American Dream. It is a continuous support system that helps everyone trying to better their lives. It depends on the circumstances, when it comes to whether or not the American Dream is achievable to everyone. It also depends on the environment that the person pursuing the American Dream is in. The American dream is attainable, it just isnt the American dream one is taught to pursue at an early age(Is the American Dream Attainable). Pursuing the American dream has become more common, which has made it more competitive. Improving one of the main factors of the American Dream, which is education, is more expensive now as well. The American Dream does not mean achieving success quickly or gaining a great amount of money easily. It means that a better life is possible with hard work and dedication. It is attainable with hope and determination. The main and most common obstacles include racism and struggles with the economy and finances. Preconceived notions of the character and work ethic of those trying to pursue the American Dream is an issue. The stereotypical idea that they cannot keep a steady job is an issue as well. Even though the rumors and ideas are false, some still believe there are no obstacles. There areShow MoreRelatedImmigrants And The American Dream1362 Words   |  6 PagesImmigrants and the American Dream In the article â€Å"The American Dream†, by James Truslow Adams in The Sundance Reader book, he stated that the American dream is that dream of a land in which life should be better and richer and fuller for everyone, with opportunity for each according to ability or achievement. It is a difficult dream for the European upper classes to interpret adequately, and too many of us ourselves have grown weary and mistrustful of it. It is not a dream of motor cars and highRead MoreThe American Dream By Kimberly Amadeo1637 Words   |  7 PagesNowadays, a large number of people migrate to the United States to work and achieve the American Dream. According to the Article â€Å"What is the American Dream?† by Kimberly Amadeo, â€Å"The American Dream was first publicly defined in 1931 by James Truslow Adams in Epic of America. Adam’s often-repeated quote is, ‘The American Dream is that dream of land in which life should be better and richer and fuller for everyon e, with opportunity for each according to ability or achievement.’† There are many peopleRead MoreAnalysis Of The Movie The American Dream 754 Words   |  4 Pages Nyreel Powell Ms. Jones American Literature 1 June 2015 The American dream in A Raisin in the Sun Have you ever had a dream and it didn’t come how you wanted it to be? Have you ever had accomplishments that you wanted to achieve but people were getting in the way of them? The four main characters in this book all have good dreams but there are people in the way of getting to those dreams or their dream is too high to accomplish. A Raisin in the Sun a play written by Lorraine Hansberry, andRead MoreSister Carrie and the American Dream1618 Words   |  7 PagesThe American Dream is surely based on the concept of â€Å"Life, Liberty and the Pursuit of Happiness† but it is above all, a matter of ambition. James Truslow Adams, an American writer and historian, in 1931 states: life should be better and richer and fuller for everyone, with opportunity for each according to ability or achievement†, which not only points towards a better standard of living for Americans but also denounces a degree of greed in the US society. Ambition not only â€Å"killed the catâ₠¬  butRead MoreGrapes Of Wrath And The American Dream1644 Words   |  7 PagesThe idea of the American Dream is ever changing depending on the person and the time of life that person is in. Although the main ideas of the American Dream remain the same to be educated, economically sound, healthy, to have a family, and equal rights. Many great films and works of literature were created to show case all the different ideas people have for their American Dream. The film â€Å"Grapes of Wrath† directed by John Ford and the poem â€Å"I Will Fight No More Forever† by Chief Joseph, both depictRead More Destruction of the American Dream Essay2145 Words   |  9 PagesDestruction of the American Dream I’ve talked about it in the past, the destruction of the American Dream. Always, there have been papers, writings, and thoughts that quantify a particular section of its ultimate demise, be it due to money, education, or sexuality. Maybe the destruction cannot be viewed as a singular event or cause. Perhaps instead it must be examined as a whole process, the decay and ultimate elimination of a dream. Self destruction, if you will†¦ Mr. Self Destruct Read MoreSuccess As One Of The American Dream1137 Words   |  5 PagesApril 2015 Success as One of The American Dream When we hear the word â€Å"success†, we often think of wealth and money. To some people, the embodiment of being success is earning a lot of money. In fact, the concept of success is primarily based on how much money a person earns. However, each person views the definition of success differently. One way to define success is something that has more to do with flash than it does with substance. John Wooden, an American basketball player and coach viewRead MoreJim Cullen And The American Dream2081 Words   |  9 Pages The American Dream, as defined by Cullen, is starting your goal off with a little and ending with more; it s like a business, you invest in it in order to gain more money. Usually, people will define the American Dream as being able to achieve your goal because everyone is offered opportunities. Cullen does acknowledge that people are born with different opportunities, so he talks about the good life. The good life describes different factors that determine your opportunities. Throughout the otherRead MoreFactors Influencing The American Dream1834 Words   |  8 Pagesindividual to succumb or to not succumb to the seductions of crime. These three factors are brilliantly portrayed in the television show, Breaking Bad and the novel, The Stick Up Kids. The American Dream is what many American citizens strive for. However, not all of those citizens are able to achieve the American Dream through a legal pathway. The reason an indivudal may not being able to do so is because of his or her background factors. It is important to note that background factors are a fractionRead MoreShark Tank And The American Dream1755 Words   |  8 PagesShark Tank and The American Dream The TV show Shark tank embodies everything the American dream represents. The show obtains successful Entrepreneurs ready to invest their own money into other Americans wanting to be just like them, reaching the American dream and become a successful entrepreneur. The show presents entrepreneurs working towards the goal of creating a business to not only gain wealth but also change the way we live today. The show is to keep the American dream alive and well while